Taking different vaccines in booster applications can be as effective and safe as getting doses from the same manufacturer, according to a new study conducted by the US National Institutes of Health (NIH). The research also says that this mixture may be even better to prevent covid-19, bringing greater protection against SARS-CoV-2 and its different variants.
The tests suggest that Moderna’s mRNA vaccine, which is not yet available in Brazil, is capable of offering greater protection against the coronavirus in all respects. In addition, the results suggest that Johnson & Johnson single-dose vaccinates may have significantly enhanced immunity to any mRNA-developed vaccine from both Moderna and Pfizer. “These data suggest that if a vaccine is approved or authorized as a booster, the immune response will be generated regardless of the first vaccination regimen against covid-19,” the research says.
To develop the study, researchers recruited about 458 people over the age of 18 in different locations across the United States, who were divided into three groups of about 150 people each. Each group had received a different vaccination schedule: two doses of the vaccine from Moderna, two from Pfizer or the single dose of the vaccine from Janssen (Johnson & Johnson).
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Next, each of the three groups of 150 people was divided into three groups of 50, and each of these subgroups received a different booster dose. Vaccines were administered between 12 to 29 weeks after the end of the initial vaccination schedule. Soon after, the researchers assessed the levels of neutralization and binding of the antibodies on the day of application, even before the booster started to take effect.
The check was then done again between 15 and 29 days after receiving the booster dose. In all vaccine combinations made, antibody levels increased between four and 56-fold. In the analysis of neutralizing antibodies, those that connect and prevent the virus from infecting cells, there was an increase of four to 20 times after the third dose was the same as the first two. In those who received different vaccines, the levels increased between six to 76 times.
Overall, therefore, people who received the Moderna vaccine had the highest levels of neutralizing antibodies, regardless of the dose they initially received. Scientists explain that the tests were not comprehensive enough. However, to say which combination offers the best protection, the study still needs to be peer reviewed.
You can check out the study neste link.
Source: ARS Technica
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