A shipment of cannabis will be sent to the ISS.  Researchers want to study the effects of microgravity on plant cells

In the last week, Oregon State University has become famous not only on the Czech political scene, but also in the field of research kanabinoidů and their effect on SARS-CoV-2 virus. Cannabinoids are found in the breast milk of mammals, including humans, but we usually associate them primarily with cannabis.

And just the ones of plant origin are in the article (PDF) Researchers from the OSU School of Pharmacy and colleagues at the Oregon University of Health and Science (OHSU) also researched the Journal of Natural Products to investigate what happens when a basic cannabis cannabinoid is used. cannabigerolic acid molecule (CBGA) – and its synthesized carboxylic acids THCA a CBDA come into contact with the virus.

Cannabinoid as an antiviral adhesive

During the experiment, all the cannabinoids mentioned acted with varying degrees of success as adhesives and bound to virus particles that could not penetrate the epithelial cells that make up our mucous membranes.

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Computer model of various forms of binding of CBGA, CBGA and THCA molecules to yellow residues of SARS-CoV-2 virus spike protein

How is it possible? In fact, it was no surprise, and for the cannabinoids, the researchers did not choose out of plain peas and because they would have enough in their pockets. Their suitability has previously been confirmed by mass spectrometry, according to which cannabinoid acid molecules have a suitable form and could to fit into critical parts of the virus as two puzzle pieces.

Cannabinoids attack the spike protein

This was eventually verified by tests with modified and some older variants of the SARS-CoV-2 virus (alpha B.1.1.7 and also beta B.1.351), in which cannabinoid acid molecules stuck the SARS-CoV-2 virus spike protein, which is now widely known and still quoted.

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CBDA and CBGA gradually neutralize the virus’s spike protein under laboratory conditions

According to the experiment, CBDA and CBGA acid molecules performed best, which, when glued together, changed the shape of the virus in such a way that it could no longer penetrate the cell and cause infection.

Thus, it has once again been confirmed that the socially stigmatized plant is the source of a unique mix of substances that could have further and previously unsuspected pharmaceutical potential in the future.

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