Genetic signature allows discovering who will develop post-vaccine immunity

An American team of scientists reveals a formula to predict how the immune system should respond to vaccines, regardless of the disease they seek to immunize. This is possible by checking a genetic signature, which varies for each individual. The discovery should revolutionize, in the future, the way immunizers are used.

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The genetic signature, which indicates how the immune system will react to an immunizer, can be found from a specific type of blood cell, plasmablasts. These are the ones that will produce the antibodies against the antigens in the body.

The measurement of this new parameter must be performed seven days after vaccination. The range is much smaller than the options available today, where scientists have to wait weeks to understand how the organism reacted to an immunizer.

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Understand the study that predicts immune system reaction after vaccination

Scientists figure out how to calculate the body’s reaction after a vaccine (Image: iLexx/Envato Elements)

To arrive at this discovery, researchers at Stanford University School of Medicine, in the United States, analyzed blood samples from 820 people between 18 and 50 years old, who received one of the 13 vaccines considered by the study.

It is worth noting that the database used contained the immune response of patients to different types of vaccines. These are the cases of immunizers that use viral vector technology or that carry a live or inactivated virus in their composition. The results were published in the scientific journal Nature Immunology🇧🇷

Future of genetic signature vaccines

“Our integrated analysis revealed a common genetic signature that predicts the strength of antibody responses to most vaccines,” says Bali Pulendran, professor of microbiology and immunology at the university, in a statement on the discovery.

If the research continues and the technology becomes popular, a person will be able to take a test a few days after being immunized and find out how the body reacted to the immunizer. If the vaccine has not triggered the desired effect, it is possible to consider other alternatives for protection with the medical team.

“We are in an exciting new moment in this field of vaccinology, with the prospect of customizing vaccines to the recipient based on these molecular signatures,” suggests Pulendran. In other words, the researcher indicates the possibility of developing specific formulas according to the characteristics of each individual, boosting immunological protection.

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