The complex and expensive process to obtain the fertility hormone

In dialogue with Fontevecchia mode for Radius Profile (FM 101.9), patrick bosioresponsible for institutional relations of the laboratory biomes detailed the process through which gonadotrophin is obtained, a hormone that is used for treatments that seek to increase fertility in women. “We are talking about a raw material in which 95% is water”, she explained, which makes the purification process very complex and expensive.

What is the collection process that is carried out in the laboratory?

– Here you receive urine donated by women across the country over 48 years old and what is done with that is to extract a hormone that is present called gonadotropin. The gonadotropin that, in the case of women, acts on ovulation once a month. So, from the moment a woman enters menopause, the body continues to generate that hormone but eliminates it in greater quantity through urine. What the laboratory does is receive that urine, process it through a complex mechanism under international standards and is purified to achieve an active ingredient used to manufacture drugs used in fertility treatmentsprocedures that serve to stimulate the production of ovules and increase the chances of conceiving.

It is one of the few laboratories in Latin America that has access to many provinces, right?

– There is donors in 19 provinces and it is one of the few in the world that does this procedure. It is complex because it involves a natural raw material and it is expensive to extract an ingredient, much more so considering that urine is 95% water. That extraction process is costly and extensive. It takes between 6 and 7 months between receiving the urine until the active ingredient is extracted.

Is there anything else that works from urine apart from this active ingredient?

– No. In the case of the Biomás laboratory, the only thing it has been producing for 25 years is gonadotropin of natural origin.

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JF: One is suspicious when something is done only in Argentina and not in the rest of the world. I ask him to explain to me why we are so different from the rest of the world…

– There are other countries where the activity exists and there are other ways to obtain gonadotropin. In the case of Argentina, it is a laboratory that is many years old. The first procedure that was invented to extract the hormone was through the use of urine, then the laboratory is dedicated to using this form because it is the method that has been used for a long time.

JF: Why is gonadotropin obtained in another way in other countries? Is there a why?

– It is a historical question. Eventually, the laboratory was established in Argentina and began to produce the hormone in this way. Other laboratories produce it in another way.

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JF: What generates mistrust is whether the method used in Argentina is validated, it is universal, if it is produced in another way in other countries, it may mean that there are certain impediments to the hormone being produced in the way it is. is done here, that maybe there are laws or issues of food science that prevent it…

– No, there is no restriction anywhere to produce the hormone in this way. Simply It’s one of several ways to get it. as it happens with many other active ingredients that can be obtained naturally.

Is there an economic issue behind it that makes this the most logical way in Argentina?

– The reality is that in terms of science, we we produce the active ingredient with which we do not manufacture the final product. But it is important to bear in mind that in the case of gonadotrophin obtained naturally, it is much more expensive than obtaining it synthetically. In the case of the laboratory, we are talking about a raw material in which 95% is water, so the procedure is complex and that has also been perfected over the last 25 years and is also a expensive raw material to obtain from a logistics point of view. There are 19 provinces where there are donors. It is a very complex logistics where the urine has to be collected very frequently, not more than two days because otherwise it spoils and the hormone breaks down. They have to be refrigerated trucks and they have to travel the entire country, which is very extensive. It is expensive to achieve from logistics to production.

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