Vaccination passport: Italy makes vaccination mandatory for workers

To measure the effectiveness of the mRNA (messenger RNA) vaccine from Pfizer/BioNTech, a new Brazilian study will vaccinate all residents over 12 years of age in Toledo, Paraná, who have not yet been immunized. In addition, local covid-19 cases will be monitored. The new study plans to understand how well and for how long the formula works against the SARS-CoV-2 coronavirus.

The study is led by Hospital Moinhos de Vento and Pfizer Brasil, in partnership with the National Immunization Program, the Federal University of Paraná and the Health Department of Toledo. In an observational way, the research will analyze the impacts of the vaccine in the prevention of symptomatic cases, reinfection, hospitalizations, deaths, adverse effects of the formula and post-covid cases.

City of Toledo will be the focus of a study on the effectiveness of the Pfizer/BioNTech vaccine against covid-19 (Image: Reproduction/FabrikaPhoto/Envato Elements)

From now on, Pfizer’s vaccines will be provided to the local population over 12 years old, which will ensure that an even larger percentage of Toledo residents have received the immunizing agent.

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understand the study

Led by the researcher and intensive care physician Regis Goulart Rosa, the study should recruit around 4,500 volunteers, of which approximately 1,500 will be followed up for a year. Recruitment will be done as people seek health services, as long as they report flu-like symptoms (suspected covid). In these cases, they will be invited to participate in the survey.

Based on a consent form, the researchers will classify the volunteers between those who test positive for the infection (case group) and negative (control group). “Information on the vaccination status of these participants will allow the evaluation of the effectiveness and safety of the vaccine in the short, medium and long term”, explained Regis, in a note.

“One of our goals is to assess the impact of mass vaccination for covid-19 with ComiRNAty [vacina da Pfizer/BioNTech] in relevant outcomes and in a context of high prevalence of worrisome variants of SARS-CoV-2, as is the case of the Gamma (P.1) and Delta variants. The research should help us to understand the effectiveness of vaccination for covid-19 in our environment, contributing to the development of immunization policies based on local and high-quality evidence”, completes the doctor.

Effectiveness: Effectiveness in the real world

With the results of the study, the effectiveness of the vaccine against covid-19 will be understood — in other words, the rate of effectiveness measured in real life. In these cases, the response to the immunizing agent must be observed in a heterogeneous group of people, with the most diverse health and age conditions, for example. Thus, the data obtained will be more realistic than those obtained so far exclusively for the Brazilian population.

It is worth remembering that studies evaluating the use of the vaccine in real life are already carried out worldwide and are necessary for the development of public strategies for the control of the pandemic. In Brazil, one of the best known is the city of Serrana, in the interior of São Paulo. In the region, the Butantan Institute vaccinated the entire city with the CoronaVac formula and observed a significant drop in transmission and in the number of hospitalizations, after immunizing at least 75% of the local population.

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